CRI's clinical tools guides
Management of patients on abatacept in daily practice

Update of the CRI fact sheets on abatacept

Since 2005, the CRI has been issuing fact sheets on each new biological agent with the goal of assisting you in your daily practice. Based on new published data and the needs of our clinical practice, these fact sheets are updated at regular intervals. They reflect the experts ‘work consisting in reviewing the literature, studying unpublished data supplied by pharmaceutical companies and communications from main professional meetings, and participating in extensive expert discussions. For all the situations that are not reflected in the Summary of Product Characteristics and for which no consensus exists, we have tried to give our concerted opinion.

As in previous fact sheets, color codes are used to differentiate evidence-based statements, official recommendations, and statements that rely on experts’ opinion.

Our fact-sheet team is now multidisciplinary, as we need expertise from diverse areas to improve our knowledge about new immunomodulating agents.

We owe a large debt of gratitude to all the contributors, who expended a tremendous amount of energy to develop these fact sheets.

Please feel free to provide feedback, in order to help us improve these fact sheets in future updates.

Avec l'aimable concours et l'autorisation de la Revue du Rhumatisme et de sa version en langue anglaise Joint Bone Spine

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Table of contents
Last update : February 2012

Rheumatoid arthritis (RA)

• Abstract
  • Initial pre-treatment assessment
  • Treatment monitoring
• Diseases: management in patients who have past or present history of...?
  • Autoimmune disease
  • Cardiovascular disease
  • Lymphoma or other hematological disorders
  • Liver abnormalities
  • Bacterial and viral infections (including tuberculosis)
  • Solid cancer
  • Infusion-related reactions, whether immediate or delayed
• Clinical situations: management of...
  • Specific situations: dialysis, hemoglobinopathy, splenectomy
  • Use of concomitant medications
  • Surgery, dental care, burns, and traumatic injuries
  • Pregnancy
  • Patient older than 75 years of age
  • Vaccination
  • Travel
• Subcutaneous abatacept
• Use of abatacept in RA
  • ​Patient information

Diseases other than RA

• Using abatacept in...
  • Juvenile idiopathic arthritis
  • Ankylosing spondylitis and other spondylarthropathies
  • Autoimmune diseases (systemic lupus erythematosus and other systemic autoimmune diseases)

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Appendices

• Model letters for informing…
  • The usual rheumatologist
  • The primary-care physician

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Members of the panel of experts:
Thao Pham (1,*), Hervé Bachelez (2), Jean-Marie Berthelot (3), Jacques Blacher (4), Pascal Claudepierre (5), Arnaud Constantin (6), Bruno Fautrel (7), Cécile Gaujoux-Viala (7), Vincent Goëb (8), Laure Gossec (9), Philippe Goupille (10), Séverine Guillaume-Czitrom (11), Eric Hachulla (12), Thierry Lequerré (8), Jean- Pierre Marolleau (13), Valérie Martinez (14), Charles Masson (15), Luc Mouthon (16), Xavier Puéchal (17), Pascal Richette (18), Alain Saraux (19), Thierry Schaeverbeke (20), Martin Soubrier (21), Manuelle Viguier (2), Olivier Vittecoq (8), Daniel Wendling (22), Xavier Mariette (23), and Jean Sibilia (24).
(1) Service de Rhumatologie, CHU Sainte-Marguerite, Marseille. (2) Service de Dermatologie, CHU Saint-Louis, Paris. (3) Service de Rhumatologie, CHU Hôtel-Dieu, Nantes. (4) Service de Cardiologie, CHU Hôtel-Dieu, Paris. (5) Service de Rhumatologie, CHU Henri Mondor, Créteil. (6) Service de Rhumatologie, CHU Purpan, Toulouse. (7) Service de Rhumatologie, CHU Pitié-Salpétrière, Paris. (8) Service de Rhumatologie, CHU de Rouen-Hôpitaux de Rouen, Rouen. (9) Service de Rhumatologie, CHU Cochin, Paris. (10) Service de Rhumatologie, CHU Trousseau, Tours. (11) Service de Pédiatrie Générale et Rhumatologie Pédiatrique, CHU Bicêtre, Le Kremlin-Bicêtre. (12) Service de Médecine Interne, CHU Hôpital Claude Huriez, Lille. (13) Service d’Hématologie, CHU Amiens-Picardie, Amiens. (14) Service de Médecine Interne et Immunologie Clinique, CHU Hôpital Antoine Béclère,Clamart. (15) Service de Rhumatologie, CHU Angers, Angers. (16) Service de Médecine Interne, CHU Cochin, Paris. (17) Service de Rhumatologie, CH Le Mans, Le Mans. (18) Service de Rhumatologie, CHU Lariboisière, Paris. (19) Service de Rhumatologie, CHU Cavale-Blanche, Brest. (20) Service de Rhumatologie, CHU Pellegrin, Bordeaux. (21) Service de Rhumatologie, CHU Gabriel-Montpied, Clermont-Ferrand. (22) Service de Rhumatologie, CHU Jean Minjoz, Besançon. (23) Service de Rhumatologie, CHU Bicêtre, Le Kremlin-Bicêtre. (24) Service de Rhumatologie, CHU Hautepierre, Strasbourg.